Giant cell arteritis (Horton's disease) in very elderly patients aged 80 years and older: A study of 25 cases
Identifieur interne : 001D70 ( Main/Exploration ); précédent : 001D69; suivant : 001D71Giant cell arteritis (Horton's disease) in very elderly patients aged 80 years and older: A study of 25 cases
Auteurs : Géraldine Muller [France] ; Hervé Devilliers [France] ; Jean-François Besancenot [France] ; Patrick Manckoundia [France]Source :
- Geriatrics & Gerontology International [ 1444-1586 ] ; 2016-06.
Abstract
Aim: Analysis of the characteristics of very elderly patients with giant cell arteritis (GCA). Methods: Patients aged 80 years and older diagnosed with GCA in our department between 1 January 2002 and 31 July 2008 were retrospectively included. For each patient, we recorded general characteristics, reason(s) for hospitalization, specialty of the physician or department that referred the patient to us, medical history, treatment at admission, GCA clinical features, time to diagnosis of GCA, biological screening and GCA treatment. Results: We analyzed 25 clinical records, 18 women and seven men with a mean age of 83.9 years. General weakness, visual loss and inflammatory syndrome were the principal reasons for hospitalization. Patients were mainly referred by general practitioners or ophthalmological departments. At diagnosis, headache and musculoskeletal disorders were the most frequent signs (52% each), before general weakness and visual disorders. Time to diagnosis was 2.2 months. Inflammatory syndrome was very frequent (92%). Biopsy of the temporal artery confirmed GCA in 16 cases. Corticosteroid therapy (CST) mean dose was 0.9 mg/kg/day. Because of the positive evolution, CST was stopped in nine patients after 22.7 ± 15 months. A total of 22 patients received a preventive osteoporosis treatment. After 3 months of CST, clinical signs and IS vanished in 22 patients. CST complications, mainly infection, appeared in 17 patients. Conclusion: Clinical and biological features of GCA in the very elderly patients of the present study were comparable with those described in the literature in younger patients. However, it must be pointed out that our patients were not compared with a younger population in this study. Geriatr Gerontol Int 2015; ●●: ●●–●●.
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DOI: 10.1111/ggi.12536
Affiliations:
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Methods: Patients aged 80 years and older diagnosed with GCA in our department between 1 January 2002 and 31 July 2008 were retrospectively included. For each patient, we recorded general characteristics, reason(s) for hospitalization, specialty of the physician or department that referred the patient to us, medical history, treatment at admission, GCA clinical features, time to diagnosis of GCA, biological screening and GCA treatment. Results: We analyzed 25 clinical records, 18 women and seven men with a mean age of 83.9 years. General weakness, visual loss and inflammatory syndrome were the principal reasons for hospitalization. Patients were mainly referred by general practitioners or ophthalmological departments. At diagnosis, headache and musculoskeletal disorders were the most frequent signs (52% each), before general weakness and visual disorders. Time to diagnosis was 2.2 months. Inflammatory syndrome was very frequent (92%). Biopsy of the temporal artery confirmed GCA in 16 cases. Corticosteroid therapy (CST) mean dose was 0.9 mg/kg/day. Because of the positive evolution, CST was stopped in nine patients after 22.7 ± 15 months. A total of 22 patients received a preventive osteoporosis treatment. After 3 months of CST, clinical signs and IS vanished in 22 patients. CST complications, mainly infection, appeared in 17 patients. Conclusion: Clinical and biological features of GCA in the very elderly patients of the present study were comparable with those described in the literature in younger patients. However, it must be pointed out that our patients were not compared with a younger population in this study. Geriatr Gerontol Int 2015; ●●: ●●–●●.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Bourgogne</li><li>Bourgogne-Franche-Comté</li></region><settlement><li>Dijon</li></settlement></list><tree><country name="France"><region name="Bourgogne-Franche-Comté"><name sortKey="Muller, Geraldine" sort="Muller, Geraldine" uniqKey="Muller G" first="Géraldine" last="Muller">Géraldine Muller</name></region><name sortKey="Besancenot, Jean Rancois" sort="Besancenot, Jean Rancois" uniqKey="Besancenot J" first="Jean-François" last="Besancenot">Jean-François Besancenot</name><name sortKey="Devilliers, Herve" sort="Devilliers, Herve" uniqKey="Devilliers H" first="Hervé" last="Devilliers">Hervé Devilliers</name><name sortKey="Manckoundia, Patrick" sort="Manckoundia, Patrick" uniqKey="Manckoundia P" first="Patrick" last="Manckoundia">Patrick Manckoundia</name><name sortKey="Manckoundia, Patrick" sort="Manckoundia, Patrick" uniqKey="Manckoundia P" first="Patrick" last="Manckoundia">Patrick Manckoundia</name><name sortKey="Manckoundia, Patrick" sort="Manckoundia, Patrick" uniqKey="Manckoundia P" first="Patrick" last="Manckoundia">Patrick Manckoundia</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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